Background

Guillain-Barré syndrome (GBS) is a rare, immune-mediated neurologic disorder of the peripheral nervous system that is characterized by ascending weakness and paralysis. Between 3000 and 6000 cases of GBS (1-2 cases/100 000 persons) are diagnosed annually in the United States. Although the etiology of GBS is unclear, molecular mimicry is thought to play a role in its pathogenesis, rarely vaccination is associated with GBS

Inclusion Criteria

MedDRA PTs:

• Acute motor axonal neuropathy,
• Acute motor-sensory axonal neuropathy,
• Autoimmune neuropathy,
• Demyelinating polyneuropathy,
• Demyelination,
• Subacute inflammatory demyelinating polyneuropathy,
• Immune mediated neuropathy,
• Guillain Barré syndrome, or
• Miller-Fisher syndrome

Exclusion Criteria

• Clinical Data and medical records,
• Race and Ethnicity,
• Days post vaccination,
• Reporter criteria