Background
Thrombosis with thrombocytopenia syndrome (TTS) is a potentially life-threatening condition associated with adenoviral-vectored COVID-19 vaccination. It presents similarly to spontaneous heparin-induced thrombocytopenia.
Publication Studied
See I, Lale A, Marquez P, Streiff MB, Wheeler AP, Tepper NK, Woo EJ, Broder KR, Edwards KM, Gallego R, Geller AI, Jackson KA, Sharma S, Talaat KR, Walter EB, Akpan IJ, Ortel TL, Urrutia VC, Walker S, Yui JC, Shimabukuro TT, Mba-Jonas A, Su JR, Shay DK. Case Series of Thrombosis with Thrombocytopenia Syndrome after COVID-19 vaccination—United States, December 2020 to August 2021 Ann Intern Med. 2022 Jan 18. Doi: 10.7326/M21-4502
Link to Publication
Period of study
December 14, 2020, through September 30, 2021
Inclusion Criteria
MedDRA PTs
Search 1
- Thrombocytopenia
- Low Platelets
Search 2
- acute myocardial infarction
- basal ganglia stroke
- brain stem stroke
- hemorrhagic stroke
- hemorrhagic transformation stroke
- ischemic stroke
- lacunar stroke
- myocardial infarction
- perinatal stroke
- silent myocardial infarction
- spinal stroke
- thrombotic stroke
- vertebrobasilar stroke
Search 3
- axillary vein thrombosis
- deep vein thrombosis
- pulmonary embolism
Search 4
- aortic embolus
- aortic thrombosis
- aseptic cavernous sinus thrombosis
- brachiocephalic vein thrombosis
- brain stem embolism
- brain stem thrombosis
- carotid arterial embolus
- carotid artery thrombosis
- cavernous sinus thrombosis
- cerebral artery thrombosis
- cerebral venous sinus thrombosis
- cerebral venous thrombosis
- femoral artery embolism
- hepatic artery embolism
- hepatic artery thrombosis
- hepatic vein embolism
- hepatic vein thrombosis
- iliac artery embolism
- jugular vein embolism
- jugular vein thrombosis
- mesenteric artery embolism
- mesenteric artery thrombosis
- mesenteric vein thrombosis
- obstetrical pulmonary embolism
- portal vein embolism
- portal vein thrombosis
- portosplenomesenteric venous thrombosis
- pulmonary artery thrombosis
- pulmonary thrombosis
- pulmonary venous thrombosis
- renal artery thrombosis
- renal embolism
- renal vein embolism
- renal vein thrombosis
- splenic artery thrombosis
- splenic embolism
- splenic thrombosis
- splenic vein thrombosis
- spontaneous heparin-induced thrombocytopenia syndrome
- subclavian artery embolism
- subclavian vein thrombosis
- superior sagittal sinus thrombosis
- thrombosis mesenteric vessel
- transverse sinus thrombosis
- truncus celiacus thrombosis
- vena cava embolism
- vena cava thrombosis
- visceral venous thrombosis
Exclusion Criteria
- Clinical Data and medical records,
- Race and Ethnicity,
- Days post vaccination,
- Reporter criteria